His Majesty has taped a intimate address regarding his experience with cancer, which will be broadcast as part of this year's fundraising initiative, run by medical research organisations and a major network.
Buckingham Palace said the King would talk about his "recovery journey" as a individual battling cancer, in a televised statement on Friday at 8pm UK time.
The recording, recorded at a royal residence recently, will highlight the importance of preventative health checks to help guarantee more people diagnose the condition at an early stage.
This represents a uncommon insight on the medical condition of the Monarch, who has been in a course of therapy since the news was shared in February 2024. Analysts suggest improbable the King will specify his specific form of cancer.
The awareness event each year collects money for clinical trials and patient care and prompts people to get health assessments to improve the chances of an early diagnosis.
The King's relative openness about his condition, and his experience as a patient, has been designed to raise awareness and to persuade more people to get tested - and this will be taken a step further with this exceptional direct participation.
To date the King's main approach to his cancer has been to keep working, maintaining a full diary alongside his frequent sessions of care, and he appears not to have wanted to be overshadowed by his diagnosis.
This year has seen the 77-year-old Monarch, taking several foreign visits, notably to Italy and Canada, and hosting the largest volume of official guests to the UK for decades, featuring the German president recently.
The upcoming charity programme on Channel 4, hosted by well-known figures such as several TV personalities, will urge people not to be frightened of getting health screenings.
The hosts have been personally touched by cancer - Davina McCall said in November she had received treatment for the disease, while another presenter was overcame a thyroid condition in the past. Host Adam Hills has previously mentioned his parent, who had stomach cancer and then later blood cancer.
The broadcast will appeal to the approximate 9m people in the UK who Cancer Research UK state are not up to date with public health checks, with an online checker to let people see if they are able for tests for breast, bowel and cervical cancer.
In an effort to demystify health tests and show the importance of early diagnosis there will be a real-time transmission from treatment centres at medical facilities in Cambridge.
"I want to reduce the stigma from cancer screening and show everyone that they are not alone in this," stated a presenter.
Currently in the UK, there are a number of publicly available checks - for specific cancers - accessible for eligible individuals.
A new scheme for lung health is also being gradually implemented for people at high risk of being diagnosed with the condition, primarily aimed at people of a certain age, who are smokers or were former smokers.
Men may discuss prostate screenings, but there is no national programme operational.
The Stand Up to Cancer campaign, which has raised over one hundred million pounds for many years, is supporting dozens of medical projects involving 13,000 patients.
King Charles, in a statement for guests at a gathering for related organisations in earlier this year, had discussed acknowledging the "intimidating and at times scary reality" for patients and their loved ones.
But he noted his personal journey of managing cancer had demonstrated that "the darkest moments of illness can be illuminated by the greatest compassion," as he thanked those who supported cancer patients.
The Palace has not revealed what kind of cancer the King has, or what treatment he has undergone. The King's cancer was identified following he had undergone a routine operation.
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